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Drug placebo ; without affecting the intestinal environment, because GBF is bulky and completely insoluble. In addition to our previous investigations in which GBF provided clinical benefits in patients with mild, moderate, or active UC, the present results may become the basis for determining the full clinical value of GBF in patients with UC both in relapse and in remission stages. Previously, it has been shown that the mechanism of colitis was preventive via multi-functional agents like GBF including the following: i ; an effect on the microflora, for example, Bifidobacterium and Eubacterium limosum produced butyrate, which acts as the first fuel for mucosa and has an anti-inflammatory effect via inhibition of nuclear factor B NF- B ; and also signal transducer and activator of transcription 3 STAT3 ; 29 ii ; high water-holding capacity compared with other waterinsoluble dietary fibers and this feature might contribute to a conspicuously high stool-forming ability in the colon improvement of bowel movement ; 16 ; . In conclusion, GBF provides clinical benefits in patients in remission prolonging remission. The treatment reduces colonic inflammation and may minimize the risk of colonic cancer in the very long-term 13, 14 ; . However, there is a need for double blind and well controlled clinical trials with long-term follow-up to fully evaluate the clinical efficacy of GBF in preventing relapse of UC together with its anticancer effect on the mucosa. Likewise, in future studies, GBF treatment alone should be compared with conventional therapy. GBF appears to be safe and well tolerated, with no dietary restrictions. Finally, we hope that this prebiotic and adjunctive treatment may contribute to a better quality of life for patients with UC. References. The best place to find the cheapest nexium drug name: nexium what is nexium.
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